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In some cases, ashwagandha may: Increase thyroid hormone levels in hypothyroid individuals Decrease thyroid hormone levels in hyperthyroid individuals Help regulate the hypothalamic-pituitary-thyroid (HPT) axis A study on bipolar patients with elevated TSH levels found that ashwagandha supplementation led to a significant reduction in TSH levels

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They inhibit intestinal CYP3A4 activity, reducing the breakdown of tacrolimus and raising blood levels

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Navid F, Colbert RA (2017) Causes and consequences of endoplasmic reticulum stress in rheumatic disease